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Mutation Information
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Mutation Site
|
G140S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
raltegravir (RTG);elvitegravir (EVG) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
31516033
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2020 |
|
Journal
|
AIDS research and human retroviruses |
|
Title
|
Week 48 Resistance Analyses of the Once-Daily, Single-Tablet Regimen Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) in Adults Living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials. |
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Author
|
Lathouwers E,Wong EY,Brown K,Baugh B,Ghys A,Jezorwski J,Mohsine EG,Van Landuyt E,Opsomer M,De Meyer S,AMBER and EMERALD Study Groups. |
|
Evidence
|
Two participants showed possible resistance to DTG and full resistance to RTG and EVG (integrase inhibitor RAMs: G140S, Q148H and G140A, Q148R) on the genotype report. Both participants had previously virologically failed on RTG.
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HIV Mutation Detail Information