|
Mutation Information
|
Mutation Site
|
G140K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
INSTIs |
|
Country
|
Africa |
Literature Information
|
PubMed PMID
|
30891603
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO. |
|
Author
|
Mboumba Bouassa RS,Mossoro-Kpinde CD,Gody JC,Veyer D,Péré H,Matta M,Robin L,Grésenguet G,Charpentier C,Bélec L |
|
Evidence
|
Two (2/18;11.1%) viruses from children treated with a first-line regimen had INSTI DRMs at codon 138 (E138K and E138T), which is known to harbour major resistance mutations, and also had the accessory mutations L74I, G140K, G140R and G163R.
|
|
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HIV Mutation Detail Information