HIV Mutation Detail Information

> G140A Search Result

Mutation Information

Mutation Site	G140A
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	INSTIs
Country	Cameroon

Literature Information

PubMed PMID	32843050
Disease	HIV infection/AIDS
Published Year	2020
Journal	Antimicrobial resistance and infection control
Title	First case of Dolutegravir and Darunavir/r multi drug-resistant HIV-1 in Cameroon following exposure to Raltegravir: lessons and implications in the era of transition to Dolutegravir-based regimens.
Author	Fokam J,Takou D,Semengue ENJ,Teto G,Beloumou G,Dambaya B,Santoro MM,Mossiang L,Billong SC,Cham F,Sosso SM,Temgoua ES,Nanfack AJ,Moudourou S,Kamgaing N,Kamgaing R,Ngako Pamen JN,Etame MMN,Bissek AZ,Elat JN,Moussi EE,Colizzi V,Perno CF,Ndjolo A,VIROFORUM.
Evidence	Another GRT, covering HIV-1 integrase (IN) region, performed on the sample plasma aliquot, revealed major RAMs, L74I, E138KQ, G140A, Q148R, and E157Q, to integrase strand transfer inhibitors (INSTI) including raltegravir, dolutegravir, bictegravir and elvitegravir.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation