|
Mutation Information
|
Mutation Site
|
G123E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
|
Combined Mutation
|
gag.H127DEL+gag.S126DEL+gag.G123E+gag.T122A |
|
Relevant Drug
|
lopinavir (LPV);darunavir (DRV) |
|
Country
|
Nigeria |
Literature Information
|
PubMed PMID
|
33144375
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
mBio |
|
Title
|
In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix. |
|
Author
|
Datir R,Kemp S,El Bouzidi K,Mlchocova P,Goldstein R,Breuer J,Towers GJ,Jolly C,Quiñones-Mateu ME,Dakum PS,Ndembi N,Gupta RK |
|
Evidence
|
A combination of four mutations (S126del, H127del, T122A, and G123E) in the p17 matrix of baseline virus generated a similar 4-fold decrease in susceptibility to LPV but not darunavir.
|
|
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HIV Mutation Detail Information