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Mutation Information
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Mutation Site
|
G120A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
S PromoterII |
|
Genotype/Subtype
|
C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
30669266
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2019 |
|
Journal
|
Viruses |
|
Title
|
Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients. |
|
Author
|
Hao R,Xiang K,Shi Y,Zhao D,Tian H,Xu B,Zhu Y,Dong H,Ding H,Zhuang H,Hu J,Li T |
|
Evidence
|
Luciferase assay revealed distinct promoter activities among SPII mutants; especially SPII of G120A mutant had a 15-fold higher activity than that of wild-type (p < 0.001).
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HBV Mutation Detail Information