|
Mutation Information
|
Mutation Site
|
G118R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
MW690052-MW690089;
MG989443.1;
MG989444.1 |
|
Relevant Drug
|
lamivudine (LAM);darunavir (DRV);ritonavir;dolutegravir (DTG);azidothymidine (AZT);tenofovir (TDF);emtricitabine (FTC) |
|
Country
|
Botswana |
Literature Information
|
PubMed PMID
|
33807382
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
Viruses |
|
Title
|
HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana. |
|
Author
|
Seatla KK,Maruapula D,Choga WT,Ntsipe T,Mathiba N,Mogwele M,Kapanda M,Nkomo B,Ramaabya D,Makhema J,Mmalane M,Mine M,Kasvosve I,Lockman S,Moyo S,Gaseitsiwe S |
|
Evidence
|
The four individuals failing DTG cART but with no documented prior exposure to RAL, their selected DRMs were E138K, G140A, Q148K, A128T; G118R, E138K; N155ND and T66A, G118R, E138EAKT Figure 3.
|
|
|
HIV Mutation Detail Information