HIV Mutation Detail Information

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Mutation Information

Mutation Site	G112D
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.G112D+rt.M230I
Relevant Drug	NNRTIs
Country	Africa

Literature Information

PubMed PMID	30894467
Published Year	2019
Journal	Journal of virology
Title	Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs.
Author	Boyer PL,Melody K,Smith SJ,Dunn LL,Kline C,Fischer DK,Dwivedi R,Clark P,Hughes SH,Ambrose Z
Evidence	Two mutations, G112D and M230I, were selected in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) by a novel nonnucleoside reverse transcriptase inhibitor (NNRTI).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation