HBV Mutation Detail Information

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Mutation Information

Mutation Site	F8L
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Genotype/Subtype	D
Viral Reference	X68292.1
Country	Italy

Literature Information

PubMed PMID	25452041
Disease	Chronic hepatitis B
Published Year	2015
Journal	The Journal of infection
Title	Specific mutations in the C-terminus domain of HBV surface antigen significantly correlate with low level of serum HBV-DNA in patients with chronic HBV infection.
Author	Mirabelli C,Surdo M,Van Hemert F,Lian Z,Salpini R,Cento V,Cortese MF,Aragri M,Pollicita M,Alteri C,Bertoli A,Berkhout B,Micheli V,Gubertini G,Santoro MM,Romano S,Visca M,Bernassola M,Longo R,De Sanctis GM,Trimoulet P,Fleury H,Marino N,Mazzotta F,Cappiello G,Spanò A,Sarrecchia C,Zhang JM,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V
Evidence	Conversely, 2 HBsAg mutations (F8L and Y100C) significantly correlated with serum HBV-DNA >100,000 IU/ml. Both mutations occurred in 1.7% of patients with serum HBV-DNA ≤2000 IU/ml and their prevalence increased up to 13% and 10.1% in patients with serum HBV-DNA >100,000 IU/ml, respectively.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation