HIV Mutation Detail Information

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Mutation Information

Mutation Site	F77L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	A1;B;URF
Relevant Drug	NRTIs
Country	German

Literature Information

PubMed PMID	30650082
Disease	HIV infection/AIDS
Published Year	2019
Journal	PloS one
Title	Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort.
Author	Machnowska P,Meixenberger K,Schmidt D,Jessen H,Hillenbrand H,Gunsenheimer-Bartmeyer B,Hamouda O,Kücherer C,Bannert N,German HIV-1 Seroconverter Study Group.
Evidence	In total, TDRMs at 46 positions in PR and RT were analysed. For a number of TDRMs, no loss could be observed during the observation period (S1 Table) and, according to their maximal duration of observation, the following TDRMs seem to survive for lengthy periods in the absence of ART: the NRTI resistance mutations D67N (5.9 years), K70R (6.9 years), F77L (10.2 years), T215E (5.9 years) and K219Q (5.9 years), the NNRTI resistance mutations A98G (6.5 years) and Y188L (5.9 years) as well as the PI mutations I54L (5.9 years) and L90M (8.4 years)

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation