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Mutation Information

Mutation Site	F68A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Nef

Literature Information

PubMed PMID	22651890
Published Year	2012
Journal	Retrovirology
Title	Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.
Author	Kuo LS,Baugh LL,Denial SJ,Watkins RL,Liu M,Garcia JV,Foster JL
Evidence	It should be noted that these three Nef mutants were expressed at levels comparable to the wild type protein (Figure 4A Lower Panel), and the V66A and G67A mutations had no impact on CD4 downregulation while F68A had only a small effect (72.3 ± 3.2% of SF2Nef activity, See Figure Figure4B4B Upper Panel).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation