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Mutation Information
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Mutation Site
|
F57A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E7 |
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Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
NC_001526.3
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Literature Information
|
PubMed PMID
|
32183180
|
|
Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism. |
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Author
|
Rice S,Kim SM,Rodriguez C,Songock W,Raikhy G,Lopez R,Henderson L,Yusufji A,Bodily J |
|
Evidence
|
Additionally, CDK8 is enriched at ISG promoters in cells containing E7 but there is reduced CDK8 enrichment in cells containing the E7 F57A mutant, suggesting that E7 regulates CDK8 occupancy at ISG promoters.
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HPV Mutation Detail Information