HIV Mutation Detail Information

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Mutation Information

Mutation Site	F53L
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR
Genotype/Subtype	B
Relevant Drug	atazanavir (ATV);lopinavir (LPV)

Literature Information

PubMed PMID	30560871
Published Year	2018
Journal	Scientific reports
Title	Characterizing early drug resistance-related events using geometric ensembles from HIV protease dynamics.
Author	Sheik Amamuddy O,Bishop NT,Tastan Bishop Ö
Evidence	Global assessment via radius of gyrationPrevious work described distinct mechanisms associated with ARV drug resistance that all point to active site expansion, namely (1) impaired hydrophobic sliding shown in the G48T/L89M double mutant with saquinavir, (2) reduced dimer stability in L24I, I50V and F53L mutants and (3) single or co-operative distal mutations.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation