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Mutation Information
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Mutation Site
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F53L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
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Relevant Drug
|
darunavir (DRV) |
Literature Information
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PubMed PMID
|
27992544
|
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Published Year
|
2016 |
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Journal
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PloS one |
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Title
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Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
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Author
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Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
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Evidence
|
The open flaps of PR20 structure (3UF3) do not show this twisted flap tip, but the open conformation flap of F53L single mutant structure (2G69) has a similar twist extending from G48 to F53L.
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HIV Mutation Detail Information