HBV Mutation Detail Information

> F514L Search Result

Mutation Information

Mutation Site	F514L
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	10628774
Disease	HBV infection
Published Year	1999
Journal	Transplantation
Title	Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin.
Author	Peters MG,Singer G,Howard T,Jacobsmeyer S,Xiong X,Gibbs CS,Lamy P,Murray A
Evidence	Sequencing of HBV polymerase gene from preliver transplantation sera did not detect the usual lamivudine resistance mutations in the YMDD motif but instead two other mutations (F514-->L, L528-->M).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation