HPV Mutation Detail Information

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Mutation Information

Mutation Site	F4V
Mutation Type	Amino acid level
Gene/Protein/Region Type	E6
Genotype/Subtype	HPV18

Literature Information

PubMed PMID	29630659
Published Year	2018
Journal	PLoS pathogens
Title	STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.
Author	Morgan EL,Wasson CW,Hanson L,Kealy D,Pentland I,McGuire V,Scarpini C,Coleman N,Arthur JSC,Parish JL,Roberts S,Macdonald A
Evidence	Valine substitution of phenylalanine at amino acid position four (F4V) generates an E6 protein incapable of destabilizing p53 and in a HPV18 life cycle model is deficient in supporting viral DNA amplification [41].

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation