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HPV Mutation Detail Information

> F47R Search Result


Mutation Information
Mutation Site F47R
Mutation Type Amino acid level
Gene/Protein/Region Type E6
Genotype/Subtype HPV16
Literature Information
PubMed PMID 19015633
Published Year 2009
Journal Oncogene
Title A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells.
Author Ristriani T,Fournane S,Orfanoudakis G,Travé G,Masson M
Evidence The E6 F47R mutant is defective for polyubiquitination and subsequent degradation of p53.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation