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Mutation Information
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Mutation Site
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F34I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpr |
Literature Information
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PubMed PMID
|
31776272
|
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Published Year
|
2020 |
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Journal
|
Journal of virology |
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Title
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HIV-1 Accessory Protein Vpr Interacts with REAF/RPRD2 To Mitigate Its Antiviral Activity. |
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Author
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Gibbons JM,Marno KM,Pike R,Lee WJ,Jones CE,Ogunkolade BW,Pardieu C,Bryan A,Fu RM,Warnes G,Rowley PA,Sloan RD,McKnight Á |
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Evidence
|
Using Vpr F34I and Q65R viral mutants, we show that nuclear localization and interaction with cullin 4A-DBB1 (DCAF1) E3 ubiquitin ligase are required for REAF degradation by Vpr.
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HIV Mutation Detail Information