HIV Mutation Detail Information

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Mutation Information

Mutation Site	F34I
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vpr

Literature Information

PubMed PMID	18039376
Published Year	2007
Journal	Retrovirology
Title	Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages.
Author	Jacquot G,Le Rouzic E,David A,Mazzolini J,Bouchet J,Bouaziz S,Niedergang F,Pancino G,Benichou S
Evidence	Other mutants with substitutions in the first alpha-helix (Vpr-A30L and Vpr-F34I) were similarly distributed between the nucleus and cytoplasm, demonstrating that this helix contains the determinants required for localization of Vpr at the NE.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation