HBV Mutation Detail Information

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Mutation Information

Mutation Site	F321L
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Genotype/Subtype	C
Country	China

Literature Information

PubMed PMID	19125938
Disease	Chronic hepatitis B
Published Year	2009
Journal	Hepatology research : the official journal of the Japan Society of Hepatology
Title	Spontaneous HBeAg seroconversion and loss of hepatitis B virus DNA after acute flare due to development of drug resistant mutants during entecavir monotherapy.
Author	Mao RC,Yin YK,Qin YL,Wu XH,Weng XH,Zhang JM,Lu M
Evidence	Interestingly, some aa substitutions I320V, F321L and L615I in the polymerase sequence were present in HBV isolates from fulminant hepatitis or in such with enhanced replication capacity, and thus will be subject to further investigation of their significance for HBV replication.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation