|
Mutation Information
|
Mutation Site
|
F2V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
29893470
|
|
Published Year
|
2018 |
|
Journal
|
Journal of cellular and molecular medicine |
|
Title
|
CIP2A facilitates the G1/S cell cycle transition via B-Myb in human papillomavirus 16 oncoprotein E6-expressing cells. |
|
Author
|
Tian Y,Chen H,Qiao L,Zhang W,Zheng J,Zhao W,Chen JJ,Zhang W |
|
Evidence
|
The ability to promote the degradation of p53 protein has been suggested as a mechanism by which E6 protein from the high‐risk HPV types exhibits oncogenic activities, so a 16E6 mutant‐F2V (Phe‐2 to Val mutation) that does not degrade p53 yet retains 16E6 activities for immortalization of HMECs was constructed as we previously described.
|
|
|
HPV Mutation Detail Information