|
Mutation Information
|
Mutation Site
|
F227L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
nevirapine (NPV) |
Literature Information
|
PubMed PMID
|
32235557
|
|
Published Year
|
2020 |
|
Journal
|
Molecules (Basel, Switzerland) |
|
Title
|
Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs. |
|
Author
|
Li TT,Pannecouque C,De Clercq E,Zhuang CL,Chen FE |
|
Evidence
|
Furthermore, compounds B3-B6 were superior to NVP (EC50 = 4.28 muM) toward the virus with double mutations F227L + V106A.
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|
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HIV Mutation Detail Information