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Mutation Information
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Mutation Site
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F220L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
S |
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Combined Mutation
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s.F220L+s.V190A;s.F220L+s.S210N;s.F220L+s.S204N |
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Genotype/Subtype
|
D |
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Viral Reference
|
X65259.1
|
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Country
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Italy; United Kingdom and Germany |
Literature Information
|
PubMed PMID
|
32312174
|
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Disease
|
Chronic hepatitis B
|
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Published Year
|
2020 |
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Journal
|
Emerging microbes & infections |
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Title
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Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection. |
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Author
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Salpini R,Battisti A,Piermatteo L,Carioti L,Anastasiou OE,Gill US,Di Carlo D,Colagrossi L,Duca L,Bertoli A,La Rosa KY,Fabeni L,Iuvara A,Malagnino V,Cerva C,Lichtner M,Mastroianni CM,De Sanctis GM,Paoloni M,Marignani M,Pasquazzi C,Iapadre N,Parruti G,Vecchiet J,Sarmati L,Andreoni M,Angelico M,Grelli S,T Kennedy P,Verheyen J,Aquaro S,Silberstein FC,Perno CF,Svicher V |
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Evidence
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These mutations lie in divergent pathways involving other HBsAg C-terminus mutations: V190A + F220L (Phi = 0.41, P = 0.003), S204N + L205P (Phi = 0.36, P = 0.005), Y206F + S210R (Phi = 0.47, P < 0.001) and S210N + F220L (Phi = 0.40, P = 0.006).
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HBV Mutation Detail Information