Mutation Information
Mutation Site
|
F220C |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Viral Reference
|
AB697502;
AB246345;
JQ801515;
AB246346;
JQ801516;
AB246339;
AB900105;
AB246342 |
Country
|
Japan |
Literature Information
PubMed PMID
|
30584239
|
Disease
|
HBV infection
|
Published Year
|
2018 |
Journal
|
Scientific reports |
Title
|
Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection. |
Author
|
Inuzuka T,Ueda Y,Arasawa S,Takeda H,Matsumoto T,Osaki Y,Uemoto S,Seno H,Marusawa H |
Evidence
|
Next, we also identified amino acid substitutions sL21S (n = 3) and sF220C (n = 4) in the MHC class II-restricted T-cell epitope region, which are reported to cause a complete loss of T-cell reactivity and anti-HBs production among individuals vaccinated against HBV in an ex vivo study
|
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