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Mutation Information
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Mutation Site
|
F219Y |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Country
|
China;Taiwan |
Literature Information
|
PubMed PMID
|
30771531
|
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Disease
|
HBV infection
|
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Published Year
|
2019 |
|
Journal
|
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases |
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Title
|
Diverse immune responses to HBV surface epitope variants after vaccine booster in adolescents immunized in infancy. |
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Author
|
Lai MW,Liang KH,Yeh CT |
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Evidence
|
For epitope 213-226, 35 samples were assayed and showed that SFCs per 106 PBMCs were 39.1 ± 2.9 (27.1–56.3), 38.5 ± 2.7 (27.4–53.9), 42.1 ± 2.4 (31.0–57.0), and 40.0 ± 3.5 (26.1–61.4) for the wild type, F219Y, L213I/F220C, and V224A/S225Y, respectively, indicating that IFN-γ-secreting cells were not affected by variants in this region (paired t-test, p > 0.01)
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HBV Mutation Detail Information