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Mutation Information

Mutation Site	F174L
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120

Literature Information

PubMed PMID	33883222
Published Year	2021
Journal	Journal of virology
Title	Species-specific valid ternary interactions of HIV-1 Env-gp120, CD4, and CCR5 as revealed by an adaptive single-amino acid substitution at the V3 loop tip.
Author	Koma T,Yokoyama M,Kotani O,Doi N,Nakanishi N,Okubo H,Adachi S,Adachi A,Sato H,Nomaguchi M
Evidence	By adaptation of 562 in CyM cells(26, 30),while a number of mutations throughout the genomewere noted, adaptive mutations that highly enhance the viral replication ability were identified within the V1/V2 loop(L124F, N132K, G150R,and F174L)and V3loop(S304G, I307V,and G310R)of Env-gp120 (Fig. 1B)

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation