|
Mutation Information
|
Mutation Site
|
F161L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
GQ872210
|
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
32216026
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2020 |
|
Journal
|
Liver international : official journal of the International Association for the Study of the Liver |
|
Title
|
Entecavir-resistant hepatitis B virus decreases surface antigenicity: A full genome and functional characterization. |
|
Author
|
Park S,Park ES,Koo JE,Park YK,Lee AR,Dezhbord M,Cho ES,Ahn SH,Kim DH,Lee JH,Lee HC,Kim KH |
|
Evidence
|
More importantly, the rtI169T mutation in the RT domain, led to the sF161L mutation in the overlapping S gene, which decreased in surface antigenicity.
|
|
|
HBV Mutation Detail Information