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Mutation Information
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Mutation Site
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F160L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Combined Mutation
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rt.F160L+rt.Q151M;rt.F160L+rt.Q151M+rt.L149I+rt.F116Y+rt.F115Y+rt.D113A+rt.G112S;rt.F160L+rt.I159L+rt.Q151M+rt.F116Y+rt.F115Y+rt.D113A+rt.G112S |
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Relevant Drug
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entecavir (ETV);lamivudine (LAM);tenofovir alafenamide (TAF);islatravir (ISL);zidovudine (AZT) |
Literature Information
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PubMed PMID
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32080249
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Published Year
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2020 |
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Journal
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Scientific reports |
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Title
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Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine. |
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Author
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Yasutake Y,Hattori SI,Tamura N,Matsuda K,Kohgo S,Maeda K,Mitsuya H |
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Evidence
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However, we found that multiple mutations, including F160L, significantly compromised viral replicability;therefore, we were unable to perform an antiviral assay to verify drug susceptibility and resistance of the mutants.
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HIV Mutation Detail Information