HBV Mutation Detail Information

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Mutation Information

Mutation Site	F134L
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Combined Mutation	rt.V142A+s.F134L
Amino acid_Mutation	T555C
Genotype/Subtype	A
Relevant Drug	lamivudine (LAM)
Country	Brazil

Literature Information

PubMed PMID	18171343
Disease	Chronic hepatitis B
Published Year	2008
Journal	Journal of gastroenterology and hepatology
Title	Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case.
Author	Bottecchia M,Ikuta N,Niel C,Araujo NM,O KM,Gomes SA
Evidence	A peak of alanine aminotransferase and aspartate aminotransferase levels occurred after 19 months of lamivudine treatment, associated with the rtM204I mutation. After 32 months, the rtM204V mutation was predominant, accompanied by the lamivudine-resistant rtL180M mutation.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation