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Mutation Information
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Mutation Site
|
F132Y |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
X |
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Combined Mutation
|
x.F132Y+x.V131I+x.K130M |
|
Amino acid_Mutation
|
T1768A |
|
Genotype/Subtype
|
B;C |
Literature Information
|
PubMed PMID
|
16094714
|
|
Published Year
|
2005 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Biological impacts of "hot-spot" mutations of hepatitis B virus X proteins are genotype B and C differentiated. |
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Author
|
Lin X,Xu X,Huang QL,Liu YQ,Zheng DL,Chen WN,Lin JY |
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Evidence
|
With regard to anti-proliferative activity, compared to standard genotype C HBx, F132Y and K130M+ V131I mutants showed lower activities, and K130M+V131I +F132Y mutant, on the other hand, showed higher activity, while the mutants of I127T and I127T+K130M+V131I showed no differences.
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HBV Mutation Detail Information