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Mutation Information
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Mutation Site
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F121Y |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Relevant Drug
|
raltegravir (RAL) |
Literature Information
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PubMed PMID
|
18702518
|
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Published Year
|
2008 |
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Journal
|
Biochemistry |
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Title
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Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. |
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Author
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Marinello J,Marchand C,Mott BT,Bain A,Thomas CJ,Pommier Y |
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Evidence
|
The aims of the present study were: 1/ to investigate and compare the effects of raltegravir and elvitegravir on the three IN-mediated reactions: 3'-processing (3'-P), strand transfer (ST) and disintegration;2/ to determine the biochemical activities of seven IN mutants (T66I, L74M, E92Q, F121Y, Q148K, S153Y and N155H) previously selected from drug-resistant patients and isolates;3/ to determine the resistance profile for raltegravir and elvitegravir in those IN mutants.
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HIV Mutation Detail Information