HIV Mutation Detail Information

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Mutation Information

Mutation Site	F121A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Nef

Literature Information

PubMed PMID	31186327
Published Year	2019
Journal	mBio
Title	Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5.
Author	Wu Y,Olety B,Weiss ER,Popova E,Yamanaka H,Göttlinger H
Evidence	More drastic replication defects were observed with single amino acid substitutions of surface-exposed Nef core domain residues (L112A, F121A, and D123A) that have been shown to impair the interaction of Nef with the endocytic fission factor dynamin 2 without affecting Nef expression levels (Fig.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation