|
Mutation Information
|
Mutation Site
|
F115Y |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.F160L+rt.Q151M+rt.L149I+rt.F116Y+rt.F115Y+rt.D113A+rt.G112S;rt.F160L+rt.I159L+rt.Q151M+rt.F116Y+rt.F115Y+rt.D113A+rt.G112S |
|
Relevant Drug
|
entecavir (ETV);lamivudine (LAM);tenofovir alafenamide (TAF);islatravir (ISL);zidovudine (AZT) |
Literature Information
|
PubMed PMID
|
32080249
|
|
Published Year
|
2020 |
|
Journal
|
Scientific reports |
|
Title
|
Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine. |
|
Author
|
Yasutake Y,Hattori SI,Tamura N,Matsuda K,Kohgo S,Maeda K,Mitsuya H |
|
Evidence
|
Of these various HBV-mimicking HIV-1 RT mutants, we found that one with triple mutations (HIV-1 RTF115Y/Y116F/Q151M) was suitable for exploring the 3TC/ETV resistant mechanism, since replication-competent HIV-1F115Y/Y116F/Q151M exhibits substantial 3TC/ETV susceptibility, compared with HIV-1Q151M and HIV-1WT.
|
|
|
HIV Mutation Detail Information