Mutation Information
Mutation Site
|
E96A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
IN |
Literature Information
PubMed PMID
|
32960169
|
Published Year
|
2020 |
Journal
|
eLife |
Title
|
Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. |
Author
|
Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB |
Evidence
|
With the exception of E96A, nearly all of the IN substitutions reduced virus titers at least 100-fold compared to the WT (Figure 2B), which corresponded with reduced levels of reverse-transcription in infected cells (Figure 2C).
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