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Mutation Information
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Mutation Site
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E94K |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Nef |
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Genotype/Subtype
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B |
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Viral Reference
|
K03455.1
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|
Country
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Boston (USA) |
Literature Information
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PubMed PMID
|
31693887
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Disease
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HIV infection/AIDS
|
|
Published Year
|
2019 |
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Journal
|
Cell reports |
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Title
|
Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity. |
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Author
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Jin SW,Alsahafi N,Kuang XT,Swann SA,Toyoda M,Göttlinger H,Walker BD,Ueno T,Finzi A,Brumme ZL,Brockman MA |
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Evidence
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To confirm that E94 and/or N116 were determinants of impaired SERINC5 downregulation function by this primary Nef clone, we reverted these polymorphisms to the consensus residue (Figure 3G, right side). Consistent with results for NL4.3 Nef, reversion of E94K or N116H alone partially rescued SERINC5 downregulation activity (to 69% and 59%, respectively) (p < 0.05 for both);while reversion of both polymorphisms enhanced this activity further (to 89%) (p < 0.001).
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HIV Mutation Detail Information