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Mutation Information
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Mutation Site
|
E93D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
17311088
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2007 |
|
Journal
|
PloS one |
|
Title
|
Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape. |
|
Author
|
Karlsson AC,Iversen AK,Chapman JM,de Oliviera T,Spotts G,McMichael AJ,Davenport MP,Hecht FM,Nixon DF |
|
Evidence
|
With regard to the responses seen in patient OP428 targeting the HLA-B8 restricted EL9 epitope (Table 5), we found that 0.8% of the CTLs were actually directed at the emerging E93D mutant epitope (93 DVKDTKEAL101) at week 63, while there was no recognition of the index sequence, 93EVKDTKEAL101.
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HIV Mutation Detail Information