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Mutation Information
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Mutation Site
|
E64K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Env |
Literature Information
|
PubMed PMID
|
31527908
|
|
Published Year
|
2019 |
|
Journal
|
PLoS pathogens |
|
Title
|
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies. |
|
Author
|
LaBranche CC,Henderson R,Hsu A,Behrens S,Chen X,Zhou T,Wiehe K,Saunders KO,Alam SM,Bonsignori M,Borgnia MJ,Sattentau QJ,Eaton A,Greene K,Gao H,Liao HX,Williams WB,Peacock J,Tang H,Perez LG,Edwards RJ,Kepler TB,Korber BT,Kwong PD,Mascola JR,Acharya P,Haynes BF,Montefiori DC |
|
Evidence
|
Additionally, E64K and A316W were introduced to stabilize the Env in the closed conformation.
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HIV Mutation Detail Information