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Mutation Information
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Mutation Site
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E560K |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp41 |
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Viral Reference
|
K02013.1
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Literature Information
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PubMed PMID
|
31796053
|
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Published Year
|
2019 |
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Journal
|
Retrovirology |
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Title
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Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry. |
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Author
|
Yuan C,Wang JY,Zhao HJ,Li Y,Li D,Ling H,Zhuang M |
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Evidence
|
The Glu560Lys/Asp/Gly (E560K/D/G) mutations in HR1 of gp41 that are selected under the pressure of N- and C-peptide inhibitors modified its molecular interactions with HR2 to change 6HB stability and peptide inhibitor binding.
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HIV Mutation Detail Information