HIV Mutation Detail Information

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Mutation Information

Mutation Site	E560G
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp41
Viral Reference	K02013.1

Literature Information

PubMed PMID	31796053
Published Year	2019
Journal	Retrovirology
Title	Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry.
Author	Yuan C,Wang JY,Zhao HJ,Li Y,Li D,Ling H,Zhuang M
Evidence	E560K mutation increased 6HB thermostability and resulted in resistance to N peptide inhibitors, but E560G or E560D as compensatory mutations destabilized the 6HB to reduce inhibitor binding and resulted in increased resistance to C peptide inhibitor, T20.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation