Mutation Information
Mutation Site
|
E560D |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Gp41 |
Viral Reference
|
K02013.1
|
Literature Information
PubMed PMID
|
31796053
|
Published Year
|
2019 |
Journal
|
Retrovirology |
Title
|
Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry. |
Author
|
Yuan C,Wang JY,Zhao HJ,Li Y,Li D,Ling H,Zhuang M |
Evidence
|
E560K mutation increased 6HB thermostability and resulted in resistance to N peptide inhibitors, but E560G or E560D as compensatory mutations destabilized the 6HB to reduce inhibitor binding and resulted in increased resistance to C peptide inhibitor, T20.
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