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Mutation Information
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Mutation Site
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E478Q |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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33374603
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Published Year
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2020 |
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Journal
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International journal of molecular sciences |
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Title
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Extended Interactions between HIV-1 Viral RNA and tRNALys3 Are Important to Maintain Viral RNA Integrity. |
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Author
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Gremminger T,Song Z,Ji J,Foster A,Weng K,Heng X |
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Evidence
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However, it was shown that the mutation of one of the residues required for binding of the divalent metal ions in the RNaseH active site of RT, E478Q, eliminated the cleavage of both RNA in an RNA/RNA hybrid and RNA in a DNA/RNA hybrid, suggesting that this activity is inherent to RNaseH.
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HIV Mutation Detail Information