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Mutation Information
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Mutation Site
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E478Q |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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17644816
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Published Year
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2007 |
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Journal
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Nucleic acids research |
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Title
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Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers. |
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Author
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Kissel JD,Held DM,Hardy RW,Burke DH |
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Evidence
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To determine whether these sites of hyperactivity were due to Fe(II) bound in the pol or RNase H active sites, wild-type RT was replaced with mutants that selectively disrupt metal ion binding in either the pol (D185N or D186N) or the RNase H (E478Q) active sites.
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HIV Mutation Detail Information