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Mutation Information
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Mutation Site
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E46A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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E7 |
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Genotype/Subtype
|
HPV16 |
Literature Information
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PubMed PMID
|
12239337
|
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Published Year
|
2002 |
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Journal
|
Journal of virology |
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Title
|
Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells. |
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Author
|
Helt AM,Funk JO,Galloway DA |
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Evidence
|
In contrast, the S-phase fraction of differentiated HFKs expressing wild type E7 (E7 WT) or E7 E46A was approximately threefold greater than that of vector-expressing cells (Table (Table11 and Fig. Fig.2B).2B).
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HPV Mutation Detail Information