|
Mutation Information
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Mutation Site
|
E39A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E2 |
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Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
8627680
|
|
Published Year
|
1996 |
|
Journal
|
Journal of virology |
|
Title
|
Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions. |
|
Author
|
Sakai H,Yasugi T,Benson JD,Dowhanick JJ,Howley PM |
|
Evidence
|
The E39A mutant was also defective for HPV16 E1 binding in vitro, suggesting that the ability of E2 protein to form a complex with E1 appears to be essential for its function as an auxiliary replication factor.
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HPV Mutation Detail Information