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Mutation Information
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Mutation Site
|
E39A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E2 |
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Genotype/Subtype
|
HPV16 |
Literature Information
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PubMed PMID
|
12565157
|
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Published Year
|
2003 |
|
Journal
|
Journal of virological methods |
|
Title
|
DNA replicative functions of highly-expressed, codon-optimized human papillomavirus proteins E1 and E2. |
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Author
|
Wang XM,Jansen KU,McClements WL |
|
Evidence
|
In contrast, however, an HPV 16 E2 mutant bearing an E39A substitution, reported previously to be severely compromised for DNA replication, was found to be reduced only two-fold in activity and, therefore, considered not sufficiently inactivated for use in vaccines that depend on endogenous protein expression.
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HPV Mutation Detail Information