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Mutation Information
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Mutation Site
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E35G |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
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Genotype/Subtype
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CRF01_AE |
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Relevant Drug
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PIs |
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Country
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China |
Literature Information
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PubMed PMID
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31914782
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Disease
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HIV infection/AIDS
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Published Year
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2020 |
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Journal
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AIDS research and human retroviruses |
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Title
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Prevalence of HIV-1 Drug-Resistance Genotypes Among Unique Recombinant Forms from Yunnan Province, China in 2016-2017. |
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Author
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Deng X,Liu J,Li J,Yang B,Shu Y,Zhang M,Dong X |
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Evidence
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The dominant mutation to NRTIs detected was M184M/V/I, which was found in 46 of the 130 samples (35.4%), followed by K70K/R/E/Q/T (8.5%) and K65K/R (6.9%). For NNRTIs, the most common drug-resistant mutations were K103K/N/R/S/T (25.4%), V179E/D/Y/T (18.9%), G190A/E/G/R/S (13.8%), and Y181C/Y (9.2%), while for PIs, these were A71T (3.8%), T74S/T (3.1%), L10V/I (1.5%), V11I (0.8%), Q58Q/E (0.8%), and E35D/G (0.8%), as shown in Figure 4.;A total of four mutation sites, including Y115F, L74LI, M41L, and E35D/G, were only detected in the URFs containing CRF01_AE, while the remaining mutation sites were detected in the URFs based on the RF B/C. Among them, A62A/V, T69D/N/T, H221H/Y, V90I, K238K/N, A71T/V, L10V/I, V11I, and Q58Q/E were only detected in the RF (B/C)
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HIV Mutation Detail Information