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Mutation Information
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Mutation Site
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E35D |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
Literature Information
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PubMed PMID
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31172041
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Published Year
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2019 |
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Journal
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ACS omega |
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Title
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Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues. |
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Author
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Agniswamy J,Kneller DW,Brothers R,Wang YF,Harrison RW,Weber IT |
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Evidence
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The reorganization of the hinge loop by mutations E35D, M36I, and S37D that breaks the ion pair anchoring the flaps and thereby increases the flap flexibility as described in the previously determined complex of PRS17 with darunavir (DRV) is also observed in the current substrate analogue complexes.
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HIV Mutation Detail Information