|
Mutation Information
|
Mutation Site
|
E35D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
darunavir (DRV) |
Literature Information
|
PubMed PMID
|
27992544
|
|
Published Year
|
2016 |
|
Journal
|
PloS one |
|
Title
|
Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
|
Author
|
Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
|
Evidence
|
In PRS17, the hinge loop cluster of mutations, E35D, M36I and S37D, contributes to the altered flap dynamics by a mechanism similar to that of PR20.
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|
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HIV Mutation Detail Information