HIV Mutation Detail Information

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Mutation Information

Mutation Site	E35D
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR
Relevant Drug	lopinavir(LPV);ritonavir
Country	UK

Literature Information

PubMed PMID	22110581
Disease	HIV infection/AIDS
Published Year	2011
Journal	PloS one
Title	Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score.
Author	Cozzi-Lepri A,Prosperi MC,Kjær J,Dunn D,Paredes R,Sabin CA,Lundgren JD,Phillips AN,Pillay D,EuroSIDA Study.,United Kingdom CHIC/United Kingdom HDRD Study.
Evidence	Among the more polymorphic PI mutations (nevertheless included in the IAS-USA December 2010 list as PI-resistance mutations) the most prevalent ones were E35D, M36I, L63P and V91S reaching a percentage ranging between 30% and 50%.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation