HPV Mutation Detail Information

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Mutation Information

Mutation Site	E232K
Mutation Type	Amino acid level
Gene/Protein/Region Type	E2
Genotype/Subtype	HPV16
Country	Japan

Literature Information

PubMed PMID	24150786
Disease	High grade squamous intraepithelial lesion; Low grade squamous intraepithelial lesion; Cervical carcinoma
Published Year	2014
Journal	Journal of medical virology
Title	Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.
Author	Hang D,Gao L,Sun M,Liu Y,Ke Y
Evidence	Furthermore, the site-directed mutagenesis revealed that E232K, which is a linked variation in the hinge region of As E2, was responsible for its enhanced repression ability.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation