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Mutation Information
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Mutation Site
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E168K |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp120 |
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Country
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America |
Literature Information
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PubMed PMID
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25174000
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Published Year
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2014 |
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Journal
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Nature chemical biology |
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Title
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A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. |
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Author
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Herschhorn A,Gu C,Espy N,Richard J,Finzi A,Sodroski JG |
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Evidence
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The sCD4-induced reduction in PG9 binding was observed for either full-length or cytoplasmic tail-deleted Env complexes expressed on the surface of 293T or HOS cells;similar results were obtained with Envs derived from wild-type HIV-1YU2 or an HIV-1JR-FL variant with E168K + N188A changes in V1/V2, which restores the integrity of the PG9 epitope in that HIV-1 strain (Supplementary Fig. 10).
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HIV Mutation Detail Information